Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

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RF ablation lesion monitoring with single wavelength PA imagin

Differential phase photoacoustic imaging for high-resolution position sensing

Photoacoustic methods that may be translatable to in vivo applications generally have limited frequency and wave vector response. As a result, the point spread function of array-based scanners at moderate frequencies may have dimensions of about 1 mm3; multiple objects within this volume cannot be resolved. Small structures, such as entangled arteriole-venule pairs, can be routinely imaged in vitro with photoacoustic microscopy, but this technology is more difficult to implement in a bedside setting. The goal of this research is to detect and sense the position of unresolved absorbers with spectral contrast, spaced by less than the conventional axial or lateral image resolution, in images acquired with an array-based imaging system. We propose a differential phase photoacoustic method to estimate the distance between two unresolved objects. Two absorbers were spaced 115 μm apart, around eight times less than the lateral image resolution. Using the proposed method, absorbers were separated and their mutual distance was successfully recovered.</p

Photoacoustic imaging for guidance of interventions in cardiovascular medicine

Imaging guidance is paramount to procedural success in minimally invasive interventions. Catheter-based therapies are the standard of care in the treatment of many cardiac disorders, including coronary artery disease, structural heart disease and electrophysiological conditions. Many of these diseases are caused by, or effect, a change in vasculature or cardiac tissue composition, which can potentially be detected by photoacoustic imaging. This review summarizes the state of the art in photoacoustic imaging approaches that have been proposed for intervention guidance in cardiovascular care. All of these techniques are currently in the preclinical phase. We will conclude with an outlook towards clinical applications.ImPhys/Acoustical Wavefield Imagin